Texas at Detroit 6:40 PM ET
A rainy day in Denver turned into a daunting night in Detroit for the Texas Rangers.
St. Louis at Washington 6:45 PM ET
A pair of teams trending in opposite directions will square off for the first of three games on Friday night, when the Washington Nationals host the visiting St. Louis Cardinals.
Milwaukee at Tampa Bay 7:05 PM ET
The Milwaukee Brewers have struggled mightily on the road while the Tampa Bay Rays simply can't get it right at home.
Chi. Cubs at NY Mets 7:10 PM ET
Memorial Day weekend, the unofficial first mile marker of the baseball season, is still two weeks away.
Philadelphia at Cleveland 7:10 PM ET
Trea Turner and the Philadelphia Phillies are riding high as they visit Cleveland for a three-game series against the Guardians, beginning Friday night.
Boston at Kansas City 7:40 PM ET
Bobby Witt Jr. had the eighth four-hit game of his career and the Kansas City Royals tied a season high with 17 hits while completing a four-game sweep of the Chicago White Sox on Thursday. However, the topic in the locker room afterward was the team's pitching.
Miami at Chi. White Sox 7:40 PM ET
Wins have been hard to come by for the Chicago White Sox, but the organization was able to celebrate with hordes of South Siders when new Pope Leo XIV was confirmed as a lifelong fan by his brother on Thursday.
Cincinnati at Houston 8:10 PM ET
With only 90 career walks in 1,842 plate appearances entering this season, Astros shortstop Jeremy Pena seemed an unlikely candidate to find a home atop the Houston batting order.
San Francisco at Minnesota 8:10 PM ET
The San Francisco Giants have good feelings going into their Friday night game against the Minnesota Twins in Minneapolis.
San Diego at Colorado 8:40 PM ET
The Colorado Rockies wrapped up a home series against the best team in the American League and now face one of the better clubs in the National League.
Baltimore at LA Angels 9:38 PM ET
The Los Angeles Angels and the Baltimore Orioles likely will be happy to see each other on Friday night when they play the first contest of a three-game series in Anaheim, Calif.
LA Dodgers at Arizona 9:40 PM ET
LA Dodgers at Arizona 9:40 PM ET
In a quirky National League West schedule backloaded with division play, two of the division's clubs will finally meet this weekend.
Toronto at Seattle 9:40 PM ET
In the past, trips to Seattle almost have felt like home games for the Toronto Blue Jays.
NY Yankees at Athletics 10:05 PM ET
The top two hitters in the majors square off Friday night when the New York Yankees face the Athletics in the opener of a three-game series in Sacramento, Calif.